Xeomin

How Do I Get Rid Of Wrinkles Between My Eyebrows?

Meet Xeomin!

XEOMIN® contains botulinum toxin type A, a protein puriﬁed from the bacterium Clostridium botulinum.

Botulinum toxin type A acts on nerve endings in muscles to prevent muscle ﬁbers from contracting. By reducing
these contractions, XEOMIN® can temporarily reduce the lines on your forehead between your brows.

XEOMIN® was approved by the US Food and Drug Administration (FDA) in July 2011. It is now widely available
to patients across the US.

Before xeomin treatment

After xeomin treatment.

FREQUENTLY ASKED QUESTIONS

WHAT IS XEOMIN^®?

XEOMIN^® (incobotulinumtoxinA) is a prescription medication injected into muscles and used to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines) in adults.XEOMIN^® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.

HOW DOES XEOMIN^® WORK?

When you squint or frown, the muscles between your eyebrows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines. Botulinum toxin type A – the active ingredient in XEOMIN^®– acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN^® can temporarily reduce the lines between your eyebrows.

IS XEOMIN^® PROVEN?

XEOMIN^® was proven effective in two randomized, double-blind, multicenter, placebo-controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years. Patients received 20 Units of XEOMIN^® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment success was higher with XEOMIN^® than placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, XEOMIN^® received FDA approval for use in glabellar lines in 2011.

HOW DO I KNOW IF XEOMIN^® IS RIGHT FOR ME?

If you are an adult with moderate to severe glabellar lines, XEOMIN^® may be right for you. Talk to your doctor to discuss the benefits and risks of treatment. Do not take XEOMIN^® if you are allergic to botulinum toxin or any of the other ingredients in XEOMIN^®. You should also not take XEOMIN^® if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.

WHAT SHOULD I TELL MY DOCTOR BEFORE TREATMENT?

Before receiving treatment with XEOMIN^®, you should tell your doctor about all of your medical conditions, including whether you have a disease that affects your muscles and nerves, have allergies to any botulinum toxin product, or have experienced any side effect from any other botulinum toxin in the past. In addition, tell your doctor about your medical history and all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you have received any other botulinum toxin product in the last four months or in the past. Be sure your doctor knows exactly which product(s) you received and when you received them.

WHAT CAN I EXPECT DURING TREATMENT?

During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN^® into the muscles in your forehead that cause frown lines between your eyebrows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.

WHEN CAN I EXPECT TO SEE RESULTS?

You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

WHAT ARE THE MOST COMMON SIDE EFFECTS OF XEOMIN^®?

XEOMIN^® may cause serious side effects, including allergic reactions. Symptoms of an allergic reaction to XEOMIN^® may include: itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or seek medical help right away if you have wheezing, experience other asthma symptoms, or if you become dizzy or faint. In clinical trials of XEOMIN^® for the treatment of frown lines between the eyebrows, headache was the most common side effect.XEOMIN^® may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of taking XEOMIN^®. If this happens, do not drive a car, operate machinery, or do other dangerous activities.
Tell your doctor if you have any side effect that bothers you or that does not subside. These are not all of the possible side effects of XEOMIN^®. For more information, see accompanying Important Safety Information, Medication Guide, and Full Prescribing Information, or ask your doctor.

ARE YOU CONCERNED ABOUT LOOKING PLASTIC OR OVERDONE?

Looking plastic or overdone is a common concern among individuals considering an in-office treatment for moderate to severe frown lines.^* Talk to your licensed, trained, healthcare professional. There are steps you can take to make you feel more comfortable. First, have a detailed discussion with your provider. You want to talk through every concern you have until you feel comfortable. Your provider, who is experienced in facial anatomy, can determine the right options for you. For example, the most widely used procedure for moderate to severe frown lines is neurotoxin injections, a class of prescription medication that has been shown to be effective in many studies. Finally, ask for an FDA-approved product, such as XEOMIN^®. Individual results may vary.

Balance Medical & Day Spa is the premier place for Xeomin injections in Columbia, Chapin, and Irmo, South Carolina. Flawless skin is our goal! Call or use our contact form to set up a consultation and get back to feeling good and looking great.

IMPORTANT SAFETY INFORMATION
XEOMIN® may cause serious side effects that can be life-threatening. Call your doctor or get medical help right
away if you have any of these problems any time (hours to weeks) after treatment with XEOMIN:
• Problems with swallowing, speaking, or breathing can happen after an injection of XEOMIN if the muscles that you
use to breathe and swallow become weak. If these problems are severe, you could die. People with certain breathing
problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing
problems with XEOMIN.
• Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and
water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or
breathing problems before receiving XEOMIN have the highest risk of getting these problems.
• Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection
site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and
muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of
voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.
Do not take XEOMIN if you: are allergic to XEOMIN or any of the ingredients in XEOMIN; had an allergic reaction to any
other botulinum toxin product such as rimabotulinumtoxinB (Myobloc®), onabotulinumtoxinA (Botox®, Botox® Cosmetic), or
abobotulinumtoxinA (Dysport®); have a skin infection at the planned injection site.
Before you take XEOMIN, tell your doctor about all your medical conditions, including if you have a disease that
affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis
or LambertEaton syndrome), as you may be at increased risk of serious side effects including difﬁculty swallowing or
breathing. Tell your doctor if you have: had any side effect from any other botulinum toxin in the past; breathing problems
such as asthma or emphysema; a history of swallowing problems or inhaling food or ﬂuid into your lungs (aspiration);
bleeding problems; drooping eyelids; plans to have surgery; had surgery on your face. Also, tell your doctor if you are
pregnant or plan to become pregnant (it is not known if XEOMIN can harm your unborn baby); are breastfeeding or plan to
breastfeed (it is not known if XEOMIN passes into breast milk).
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and
herbal products. Using XEOMIN with certain other medicines may cause serious side effects. Do not start any new
medicines until you have told your doctor that you have received XEOMIN in the past.
Especially tell your doctor if you have received any other botulinum toxin product in the last four months or in the past.
Be sure your doctor knows exactly which product you received. The dose of XEOMIN may be different from other botulinum
toxin products that you have received. Tell your doctor if you: have recently received an antibiotic by injection; take muscle
relaxants; take an allergy or cold medicine; take a sleep medicine; take a blood thinner medicine.
XEOMIN may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks
of taking XEOMIN. If this happens, do not drive a car, operate machinery, or do other dangerous activities.
XEOMIN may cause other serious side effects including allergic reactions. Symptoms of an allergic reaction to
XEOMIN may include: itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your
doctor or get medical help right away if you get wheezing or asthma symptoms, or if you get dizzy or faint.
Headache was the most common side effect of XEOMIN for treatment of glabellar lines. Other side effects of
XEOMIN include: dry mouth, discomfort or pain at the injection site, tiredness, neck pain, muscle weakness, and eye
problems, including double vision, blurred vision, drooping eyelids, swelling of your eyelids, and dry eyes. Reduced blinking
can also occur. Tell your doctor or get medical help right away if you have eye pain or irritation following treatment.
Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side
effects of XEOMIN. For more information, ask your doctor or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

Please see Full Prescribing Information and Medication Guide for more information.